Rescue of bicoid mutant Drosophila embryos by Bicoid fusion proteins containing heterologous activating sequences
- 1 November 1989
- journal article
- Published by Springer Nature in Nature
- Vol. 342 (6246) , 149-154
- https://doi.org/10.1038/342149a0
Abstract
The maternal gene bicoid (bcd) determines pattern in the anterior half of the Drosophila embryo. It is reported here that the injection of bcd mutant embryos with messenger RNAs that encode proteins consisting of heterologous acidic transcriptional activating sequences fused to the DNA-binding portion of the bcd gene product, can completely restore the anterior pattern of the embryo.Keywords
This publication has 48 references indexed in Scilit:
- Determination of spatial domains of zygotic gene expression in the Drosophila embryo by the affinity of binding sites for the bicoid morphogenNature, 1989
- The bicoid protein is a positive regulator of hunchback transcription in the early Drosophila embryoNature, 1989
- The bicoid protein determines position in the Drosophila embryo in a concentration-dependent mannerPublished by Elsevier ,1988
- A gradient of bicoid protein in Drosophila embryosCell, 1988
- Regulation of the Drosophila segmentation gene hunchback by two maternal morphogenetic centresNature, 1988
- Finger protein of novel structure encoded by hunchback, a second member of the gap class of Drosophila segmentation genesNature, 1987
- hunchback, a gene required for segmentation of an anterior and posterior region of the Drosophila embryoDevelopmental Biology, 1987
- Structure of the segmentation gene paired and the Drosophila PRD gene set as part of a gene networkCell, 1986
- Organization of anterior pattern in the Drosophila embryo by the maternal gene bicoidNature, 1986
- A conserved DNA sequence in homoeotic genes of the Drosophila Antennapedia and bithorax complexesNature, 1984