FAILURE TO INDUCE TOLERANCE TO RAT TISSUE ANTIGENS

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  • 1 January 1967
    • journal article
    • research article
    • Vol. 13  (4) , 373-+
Abstract
Rats subjected to an intensive injection schedule from birth for 5 weeks with rat liver antigen failed to show immunological tolerance with respect to the production of heat-labile and heat-stable high molecular weight antibody when challenged with liver antigen or carbon tetrachloride. Particulate subcellular components of the animals'' own tissues, like foreign particulate antigens, may not readily induce tolerance and that this may explain the finding of anti-tissue antibodies in various human diseases particularly following tissue breakdown.