Synapse Elimination in the Central Nervous System: Functional Significance and Cellular Mechanisms
- 1 January 1996
- journal article
- review article
- Published by Walter de Gruyter GmbH in Reviews in the Neurosciences
- Vol. 7 (2) , 85-102
- https://doi.org/10.1515/revneuro.1996.7.2.85
Abstract
Recent research into the developmental elimination of supernumerary synapses has increased understanding of this process. In this review we discuss synapse elimination both at the neuromuscular junction and in the central nervous system, considering some possible underlying mechanisms suggested by recent studies. In addition a well-described example of central nervous system synapse elimination, the climbing fiber-Purkinje cell synapse of the cerebellum, is used to explore the functional significance of synaptic regression during brain development.Keywords
This publication has 95 references indexed in Scilit:
- Abnormal ipsilateral functional vibrissae projection onto Purkinje cells multiply innervated by climbing fibers in the ratDevelopmental Brain Research, 1995
- Retrograde interactions during formation and elimination of neuromuscular synapsesCurrent Opinion in Neurobiology, 1994
- Gradual loss of synaptic cartels precedes axon withdrawal at developing neuromuscular junctionsNeuron, 1993
- Early development of the Lurcher cerebellum: Purkinje cell alterations and impairment of synaptogenesisJournal of Neurocytology, 1992
- Activity-Dependent Synaptic Competition in Vitro: Heterosynaptic Suppression of Developing SynapsesScience, 1991
- The effect of neuronal activity on the competitive elimination of neuromuscular junctions in tissue cultureDevelopmental Brain Research, 1986
- Transitory macrophages in the white matter of the developing visual cortex. II. Development and relations with axonal pathwaysDevelopmental Brain Research, 1983
- Fate of the multiple innervation of cerebellar Purkinje cells by climbing fibers in immature control, X-irradiated and hypothyroid ratsDevelopmental Brain Research, 1981
- Differential role of granule cells in the specification of synapses between climbing fibers and cerebellar Purkinje cells in the ratNeuroscience Letters, 1978
- Multiple innervation of purkinje cells by climbing fibers in the cerebellum of the weaver mutant mouseJournal of Neurobiology, 1976