Pharmacokinetic Studies of Trimethoprim-Sulfamethoxazole in Children with Gastroenteritis

Publisher Website
Google Scholar
Abstract
Certain pharmacokinetic parameters of the combination, trimethoprim-sulfamethoxazole (TMP-SMZ), were evaluated in 25 children, aged 10 months to 15 years, with gastroenteritis. The drugs were well absorbed. Peak levels in serum were achieved within 1 hr. At doses of 100 mg of SMZ/kg per day and 20 mg of TMP/kg per day divided into four doses, the mean concentrations of SMZ (free) and TMP in serum 2 hr after the ninth dose were 173.5 and 9.6 µg/ml, respectively. At the same time, the urine contained 330 µg of TMP/ml, 881 µg of free SMZ/ml, and 2,026 µg of total SMZ/ml. The mean ratios of free SMZ to TMP for serum and urine were 23.8 and 2.9, respectively. Two patients were studied in detail. About 50% of the daily administered SMZ was recovered in the urine, with 55% of that fraction acetylated; 40% of TMP was recovered as such in the urine. The drugs were tolerated well (rash in two patients; vomiting in three patients) and laboratory assessment of hepatic, hematopoietic, and renal function revealed no abnormalities during or after seven days of therapy.

This publication has 0 references indexed in Scilit: