Cortical Modification of an Epileptogenic Focus
- 1 August 1979
- Vol. 20 (4) , 387-393
- https://doi.org/10.1111/j.1528-1157.1979.tb04818.x
Abstract
The influence of cerebral cortex on penicillin-induced spikes in striate cortex was studied in 12 cats with the technique of hypothermic block. Direct cooling of the involved or contralateral striate cortex markedly reduced seizure activity. Significant reduction in seizure activity was also seen with cooling of ipsilateral and contralateral visual association cortex. None of the other cortical areas tested had a reproducible effect on the frequency of seizures. These findings are discussed in terms of local and remote factors influencing the epileptogenic focus.Keywords
This publication has 25 references indexed in Scilit:
- Geniculate interactions with a penicillin discharge in visual cortexExperimental Neurology, 1973
- The Influence of the Cerebellum in Cat Penicillin EpilepsyEpilepsia, 1972
- Effects of lesions in ventral anterior thalamus on experimental focal epilepsyExperimental Neurology, 1972
- The importance of the caudate nucleus in the control of convulsive activity in the amygdaloid complex and the temporal cortex of the catElectroencephalography and Clinical Neurophysiology, 1971
- Modification of Focal Cortical Epileptogenic Discharge by Afferent InfluencesEpilepsia, 1966
- Cortical cellular phenomena in experimental epilepsy: Interictal manifestationsExperimental Neurology, 1964
- Intracellular Potentials of Cortical Neurons during Focal Epileptogenic DischargesScience, 1963
- Experimental and Clinical Research of Conditioned Reflex EpilepsyEpilepsia, 1962
- Hypothermia and Electrical Activity of Cerebral CortexArchives of Neurology, 1961
- Electrophysiological studies on epileptogenic lesions of cat cortexElectroencephalography and Clinical Neurophysiology, 1960