Effect of Oral Sarafloxacin Dose and Dose Duration onEdwardsiella ictaluri-Infected Channel Catfish

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Abstract
An oral dose titration was conducted to assess the efficacy of sarafloxacin-hydrochloride (Sarafin®) against Edwardsiella ictaluri infections in channel catfish. Doses of 0, 2, 6, 10, and 14 mg sarafloxacin/kg of fish were administered for 5 or 10 d in feed given at a rate of 2% of total fish weight. Mean percent mortalities at the end of the 5-d trial of the different sarafloxacin doses were as follows: 0 mg/kg, 86.1%; 2 mg/kg, 55.6%; 6 mg/kg, 44.4%; 10 mg/kg, 5.6%; and 14 mg/kg, 2.8%. After the 10-d trial doses, the mean percent mortalities were as follows: 0 mg/kg, 75.0%; 2 mg/kg, 71.5%; 6 mg/kg, 47.2%; 10 mg/kg, 0.0%; and 14 mg/kg, 2.8%. Analysis of variance indicated no significant difference in efficacy between the 5- and 10-d treatments. Pairwise comparison of the combined 5- and 10-d dose responses indicated that the sarafloxacin treatment at 2 mg/kg was not significantly different from no sarafloxacin treatment, but that the sarafloxacin dose of 6 mg/kg was significantly more effective (...

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