Distribution of Hg203-Labeled Mercaptomerin in Organs of Normal Rabbits.

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Abstract
Mercaptomerin sodium tagged with Hg203 was given to 6 normal rabbits in a dosage providing 1 mg of Hg/kg weight and its tissue distribution was determined 48 hours later. Radioactivity assay was performed by gamma counting in a well-type scintillation probe. The mean total renal content was 2.5% of the given dose of Hg at a concentration of 5.71 [mu]g/g of tissue (wet weight). The next highest concentration and content were found in the liver (0.69% and 0.26 [mu]g/g, respectively). Other organs contained negligible concentrations of Hg. In 6 other rabbits, administration of the same dosage of tagged mercaptomerin sodium on 2 consecutive days resulted 48 hours later in a renal content of 3.21% of the total amount given, at a mean concentration of 9.87 [mu]g/g. The hepatic concentration and content were 0.94% and 0.48 [mu]g/g, respectively. Other tissues showed very little cumulative effect.