MASS CHEMOPROPHYLAXIS OF TUBERCULOSIS - ACCEPTABILITY AND UNTOWARD SIDE EFFECTS OF ISONIAZID IN A CONTROL STUDY IN GREENLAND

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Abstract
In July, 1956, a control study of prophylactic isoniazid was started in the general adult population of 79 villages in West Greenland. By random allocation of the villages into 2 groups, about equal numbers of persons took either isoniazid or placebo, 5000 in each group. The program was carried out 2 days a week for 2 periods of 13 weeks each, separated by an interval of 13 weeks. The daily dose of isoniazid was 400 mg for the majority and 600 mg for a small subgroup. Despite uncertainties, pill consumption seemed to be carried out satisfactorily by 82% of the isoniazid group and 85% of the placebo group. Spontaneous complaints of symptoms were made by about 1% of each group. The symptoms were similar in both groups. Although no serious side effects occurred in either group, some indications were found that isoniazid may have caused specific subjective side effects in some persons.

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