Protease-Sensitive Fluorescent Nanofibers
- 5 October 2007
- journal article
- research article
- Published by American Chemical Society (ACS) in Bioconjugate Chemistry
- Vol. 18 (6) , 1701-1704
- https://doi.org/10.1021/bc070054z
Abstract
We report the design and synthesis of enzyme-responsive nanofibers. The fibers are composed of self-assembled hydrophobic β-sheet peptides incorporating protease-sensitive domains, fluorescent reporters, and hydrophilic poly(ethylene glycol) (PEG) units. Using urokinase plasminogen activator (uPA) as a model system, nanofibers were developed to release fluorescent fragments upon uPA incubation. These protease-sensitive nanofibers may have considerable biomedical applications as diagnostic sensors or for protease-assisted drug deliveries.Keywords
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