Electrogenic Ion Transport in Duodenum, an Aid in Cystic Fibrosis Diagnosis
- 1 January 2000
- journal article
- research article
- Published by Taylor & Francis in Scandinavian Journal of Gastroenterology
- Vol. 35 (10) , 1106-1109
- https://doi.org/10.1080/003655200451252
Abstract
Abnormality in chloride transport across epithelial tissues is a basic defect in cystic fibrosis (CF). Our aim was to compare the induced chloride secretion in duodenum in CF patients with different mutations. Duodenal biopsies from 9 patients were investigated in a modified Ussing chamber and the secretory response to prostaglandin E2 (PGE2) and acetylcholine (ACh) were measured. PGE2 and ACh induced no changes in chloride secretion in the AF508 homozygotes. In heterozygotes the induced change in chloride secretion corresponded to the severity of the known mutations. The secretory response in duodenum in CF is influenced by the patients genotype and mainly related to sweat chloride secretion.Keywords
This publication has 9 references indexed in Scilit:
- Electrogenic Ion Transport along the Human Duodenum in ChildhoodScandinavian Journal of Gastroenterology, 1997
- CYSTIC FIBROSIS: GENOTYPIC AND PHENOTYPIC VARIATIONSAnnual Review of Genetics, 1995
- Correlation of sweat chloride concentration with classes of the cystic fibrosis transmembrane conductance regulator gene mutationsThe Journal of Pediatrics, 1995
- Calcium and cAMP activate different chloride channels in the apical membrane of normal and cystic fibrosis epithelia.Proceedings of the National Academy of Sciences, 1991
- The Relation between Genotype and Phenotype in Cystic Fibrosis — Analysis of the Most Common Mutation (ΔF508)New England Journal of Medicine, 1990
- Identification of mutations in regions corresponding to the two putative nucleotide (ATP)-binding folds of the cystic fibrosis gene.Proceedings of the National Academy of Sciences, 1990
- Evidence for reduced Cl‐ and increased Na+ permeability in cystic fibrosis human primary cell cultures.The Journal of Physiology, 1988
- Failure to induce secretion in jejunal biopsies from children with cystic fibrosis.Gut, 1988
- Altered intestinal chloride transport in cystic fibrosisThe FASEB Journal, 1988