Lipid and Fatty Acid Composition of Myelin Purified from Normal and MS Brains

Publisher Website
Google Scholar
Abstract
The concentrations of phospholipids and galactolipids and their fatty acid compositions were determined in purified myelin from apparently normal white matter of 11 multiple sclerosis (MS) and 11 control brains. Myelin from MS brains showed a significant decrease in serine phosphatide and a slight decrease in the ethanolamine phosphatide fraction when compared with normal myelin; increases were found in the lysocholine and lysoethanolamine phosphoglycerides. In the galactolipids, lower figures were obtained for sulfatides, resulting in a higher cerebroside/sulfatide ratio for MS myelin. Analysis of the fatty acid pattern of phospholipids in MS brains revealed lower values for 18:1 and, except for the lyso compounds, slightly higher amounts for 20:4 and 22:6. Lower levels for the sum of 18:3 and 20:1 fatty acids were found for the EPG and IPG fractions.

This publication has 0 references indexed in Scilit: