Assessment of Risk for Chromosomal Abnormalities at 10–14 Weeks of Gestation by Nuchal Translucency and Maternal Age in 5,210 Fetuses at a Single Centre

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Abstract
Objective: To evaluate the screening of chromosomal abnormalities by nuchal translucency (NT) measurement. Methods: Assessment of risk for chromosomal abnormalities by NT and maternal age in 5,210 single fetuses with karyotype and outcome already known. Results: Risk was ≥1 in 300 in 640 (12.2%) of all fetuses, in 575 (11.1%) of the normal fetuses, in 38 (80.8%) of the fetuses affected by trisomy 21, and in 65 (89%) of the fetuses affected by chromosomal abnormalities. Risk was ≥1 in 200 in 477 (9.1%) of all fetuses, in 418 (8.1%) of the normal fetuses, in 35 (74.4%) of the fetuses affected by trisomy 21, and in 59 (80.8%) of the fetuses affected by chromosomal abnormalities. Risk was ≥1 in 100 in 270 (5.1%) of all fetuses, in 216 (4.2%) of the normal fetuses, in 33 (70.2%) of the fetuses affected by trisomy 21, and in 54 (73.9%) of the fetuses affected by chromosomal abnormalities. Conclusions: Risk generated by NT and maternal age is effective in screening for chromosomal abnormalities.