The intestinal absorption of folates

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Abstract
Dietary folates, existing primarily in the form of pteroylpolyglutamates, are absorbed in the jejunum by a process involving hydrolysis and subsequent intestinal transport of pteroylmonoglutamyl folate. Current evidence indicates that one (or more) intestinal mucosal enzyme(s), termed folate conjugase, is required for the hydrolysis of pteroylpolyglutamate to pteroylmonoglutamyl folate. Unresolved controversies include the mucosal location of hydrolysis (surface versus intracellular), whether the transport of pteroylmonoglutamate is active or passive, and the relation of intestinal mucosal metabolism of pteroylmonoglutamate to its intestinal transport.

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