Binding and Activation of Human Plasminogen by Mycobacterium tuberculosis
Open Access
- 1 July 2000
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 68 (7) , 4327-4330
- https://doi.org/10.1128/iai.68.7.4327-4330.2000
Abstract
The first evidence of the interaction of Mycobacterium tuberculosis with the plasminogen system is herein reported. By FACScan analysis and affinity blotting, lysine-dependent binding of plasminogen to M. tuberculosis was demonstrated. The binding molecules were 30-, 60-, and 66-kDa proteins present in cell wall and soluble protein extracts. The activation of plasminogen, which occurred only in presence of fibrin and was not inhibited by the host serpin, α 2 -antiplasmin, was also demonstrated.Keywords
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