Heterogeneity of insulin‐dependent diabetes–new evidence

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Abstract
Complex segregation and linkage analysis were performed in 182 families with at least 1 insulin-dependent diabetic proband. All families were typed for B histocompatibility (HLA) antigens and 118 for DR. The recessive model fit the data best, with maximum likelihood estimates of recombination beteween HLA DR and the susceptibility factor of 0.019. Substantial heterogeneity was suggested, with the smallest estimated recombination for pedigrees whose probands have 2 high-risk DR alleles. The results are compatible with a strong, tightly HLA-linked susceptibility factor and evidence for additional non-HLA linked genetic factor(s).