Uterine Cervical Lymphoepithelial-like Carcinoma: Absence of Epstein–Barr Virus Genomes

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Abstract
A poorly differentiated squamous cell carcinoma of the cervix with marked lymphoplasmacytic stromal infiltration is described in a 21-year-old black woman who had postcoital bleeding. Histologic features were strikingly similar to the classic lymphoepithelioma of the nasopharynx. Serologic evidence for remote Epstein-Barr virus infection was present. However, polymerase chain reaction amplification and hybridization of DNA extracted from fresh-frozen tumor tissue failed to identify Epstein–Barr virus genomic DNA. No human papillomavirus DNA was detected by polymerase chain reaction amplification. The histologic and Epstein–Barr virus results of the uterine cervical lymphoepitheliomal-like carcinoma were compared to the classic nasopharyngeal lymphoepithelioma and to similar tumors studied from other anatomic sites.

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