Adrenocortical dysfunction in acute medical illness
- 1 September 1986
- journal article
- Published by Wolters Kluwer Health in Critical Care Medicine
- Vol. 14 (9) , 789-791
- https://doi.org/10.1097/00003246-198609000-00006
Abstract
To further characterize the adrenocortical response to acute illness, we measured basal and adrenocorticotropic hormone (ACTH)-stimulated 11-deoxycortisol, androstenedione, and dehydroepiandrosterone sulfate (DHEAS). Acutely ill patients had higher ACTH-stimulated 11-deoxycortisol and androstenedione, and decreased basal and ACTH-stimulated androstenedione/cortisol and DHEAS/cortisol ratios. Our data suggest that a shift away from androgen synthesis toward the glucocorticoid pathway occurs in acute illness.Keywords
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