Vascular Relationships of Tumor and Host*

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Abstract
The formation, morphology, and physiology of the vascular systems of tumors are reviewed. It is suggested that certain discrepancies in the literature might be resolved by considering two types of tumor blood supplies, one appropriated from existing normal tissue and the other newly generated through a fibrovascular stromal reaction. The blood supply of intrahepatic hepatomas is considered as a special case which led to the successful identification of eleven vascular antigens, six of them in hepatoma, and possibly seven. One of the six, possibly specific for hepatoma, is reconsidered in the light of hitherto unpublished data. In a note to cancer chemotherapists it is pointed out the successful chemotherapeutic treatment of the 105 different varieties of human cancer might require a greater knowledge of their varied vasculatures than is now available.