Intradermal Vaccination in Healthy Adults With Type A Asian Strain Influenza Vaccine.

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Abstract
The immune response elicited by 2 intradermal injections of 0.1 ml monovalent Asian A influenza vaccine administered 2 weeks apart was related to the antigenic potency of the vaccine. Individuals developing detectable antibodies 2 weeks after the second injection varied with dose from 44 to 70% with titers 1:40 or greater. Using the same lot and dosage schedule of vaccine an intradermal booster immunization administered 53 weeks after first vaccinations, induced marked rise in titers which were also related to dose. The geometric mean titers which ranged from 1:21 to 1:51 two weeks after second injection of vaccine rose to 1:51 to 1:211, 2 weeks after booster injection. In the present study, 2 separate injections of 50 CCA units resulted in better antibody responses than single injections of 100 CCA units. Even the response to 2 injections of 12.5 CCA units is as good as the response to single doses 4 times as large. Systemic and local reactions increased with unit dose of vaccine but no serious reactions occurred with the lot of vaccine used throughout this study.

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