Lipoatrophic Panniculitis: A Possible Autoimmune Inflammatory Disease of Fat
- 1 December 1987
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Dermatology
- Vol. 123 (12) , 1662-1666
- https://doi.org/10.1001/archderm.1987.01660360090018
Abstract
• We observed three children with a clinically similar presentation of erythematous nodules that expanded centrifugally leaving lipoatrophy. Areas of lipoatrophy coalesced, resulting in clinical pictures similar to partial or total lipodystrophy. Histologic study revealed a lobular panniculitis with a mixed infiltrate of lymphocytes and mononuclear phagocytes. Of these three children, one had insulin-dependent diabetes mellitus and Hashimoto's thyroiditis, one developed juvenile rheumatoid arthritis, and the third developed insulin-dependent diabetes mellitus, suggesting that the pathogenic mechanism may be an expression of autoimmunity. (Arch Dermatol1987;123:1662-1666)Keywords
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