Insulin-like Growth Factor 1 as an Intra-ovarian Hormone — an Integrated Hypothesis and Review
- 1 February 1989
- journal article
- review article
- Published by Wiley in Australian and New Zealand Journal of Obstetrics and Gynaecology
- Vol. 29 (1) , 30-37
- https://doi.org/10.1111/j.1479-828x.1989.tb02872.x
Abstract
Fourteen ovulatory patients undergoing diagnostic laparoscopy had at least 2 samples of clear follicular fluid (FF) collected in the late follicular phase. Dominant follicles contained significantly higher concentrations of insulin-like growth factor-1 (IGF1), oestradiol (E2), progesterone (P) and lower androstenedione (AD) than their matched cohorts. After the luteinizing hormone (LH) surge, a significant increase in dominant FF-IGF1 and FF-P occurred. Log FF-E2 and log FF-P were correlated with both FF-IGF1 and FF volume. Log FF-AD was negatively correlated with FF-volume, FF-E2 and FF-P (but not FF-IGF1). The cohort concentration of FF-IGF1 was correlated with serum IGF1. These results support the hypothesis that IGF1 has a central role in the selection of the dominant follicle.Keywords
This publication has 21 references indexed in Scilit:
- A COMPARISON OF FOLLICULAR FLUID LEVELS OF INSULIN‐LIKE GROWTH FACTOR‐1 IN NORMAL DOMINANT AND COHORT FOLLICLES, POLYCYSTIC AND MULTICYSTIC OVARIESClinical Endocrinology, 1988
- What are the Ultrasound and Biochemical Features of Impending Ovulation?Australian and New Zealand Journal of Obstetrics and Gynaecology, 1988
- Fibroblast growth factor as an intraovarian hormone: differential regulation of steroidogenesis by an angiogenic factorRegulatory Peptides, 1986
- GROWTH HORMONE INCREASES OVARIAN LEVELS OF IMMONOREACTIVE SOMATOMEDIN C/INSULIN-LIKE GROWTH FACTOR IIN VIVO.Endocrinology, 1986
- Somatomedin-C-Mediated Potentiation of Follicle-Stimulating Hormone-Induced Aromatase Activity of Cultured Rat Granulosa Cells*Endocrinology, 1985
- Somatomedin-C Synergizes with Follicle-Stimulating Hormone in the Acquisition of Progestin Biosynthetic Capacity by Cultured Rat Granulosa Cells*Endocrinology, 1985
- Actions of Insulin-Like Growth FactorsAnnual Review of Physiology, 1985
- 7 Somatomedin activity in disorders of nutrition and metabolismClinics in Endocrinology and Metabolism, 1984
- 6 Factors controlling blood concentration of somatomedin CClinics in Endocrinology and Metabolism, 1984
- RELATIONSHIP BETWEEN FOLLICLE-STIMULATING HORMONE, ANDROSTENEDIONE AND OESTRADIOL IN HUMAN FOLLICULAR FLUIDJournal of Endocrinology, 1978