Metabolism of 5-Hydroxytryptamine (Serotonin) by Monoamine Oxidase.

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Abstract
On the basis of: (1) comparable rates of 5 hydroxy-tryptamine (5HTA) and tyramine metabolism in tissues of dog, rat and rabbit; (2) comparable inhibition of metabolism of both amines by 1-isonicotinyl-2-isopropyl-hydrazide (IIH), a potent monoanime oxidase inhibitor; (3) a demonstration that 5HTA is metabolized by the mitochondrial portion of the liver cell; and (4) a prolongation of the effects of 5HTA in vivo following pre-treatment with IIH, it is concluded that monoamine oxidase is the major pathway of 5HTA metabolism in animals.