The Histochemistry of Fibrinolysis in Haemophilic Synovial Membranes

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Abstract
Haemophilic synovial membranes obtained by synovectomy have been histochemically studied for the locausation of plasminogen activator. In the two histological types of synovial membrane (vascular and fibrous type), different degrees of fibrinolysis were detected. Higher fibrinolytic activity was found in the vascular type of haemophilic synovial membrane as compared to the normal synovial tissues. Activity was low or absent in the synovial membrane undergoing a process of fibrosis. These results may help to explain the mechanism of bleeding in haemophilic joints.

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