Total Synthesis of cis,cis-Ceratospongamide, a Bioactive Thiazole-Containing Cyclic Peptide from Marine Origin

31 December 2001

journal article
letter
Published by Georg Thieme Verlag KG in Synlett

Vol. 2001 (Special ) , 0986-0988
https://doi.org/10.1055/s-2001-14641

Abstract

The first total synthesis of cis,cis-ceratospongamide (1a), isolated from marine source, was accomplished via thiazole synthesis using CMD methodology, DEPC-mediated peptide coupling, macrolactamization, and cyclodehydration. Comparison of the cyclization sites and coupling reagents in the macrolactamization step was also investigated.

Keywords

CERATOSPONGAMIDE
CHEMICAL MANGANESE DIOXIDE (CMD)
MACROLACTAMIZATION
CYCLIC PEPTIDE
TOTAL SYNTHESIS

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