Induction of the Bioconversion of Leucomycins by Glucose and Its Regulation by Butyrate
- 1 April 1979
- journal article
- research article
- Published by Oxford University Press (OUP) in Agricultural and Biological Chemistry
- Vol. 43 (4) , 833-839
- https://doi.org/10.1080/00021369.1979.10863540
Abstract
Leucomycin A1 (LM A1) was converted to leucomycin A3 (LM A3) by Streptomyces kitasatoensis is glucose-containing medium. On the other hand, butyrate, one of the precursors of the aglycone, repressed the bioconversion of LM A1 to A3. The role of butyrate has been examined in connection with that of glucose. It was found that the production of the enzyme which catalyzes the acetylation at C–3 of aglycone was induced by glucose, and that the induction was remarkably repressed by butyrate. Cerulenin, a specific inhibitor of fatty acid synthesis, was effectively employed for the bioconversion experiments.This publication has 1 reference indexed in Scilit:
- Inhibition of the Biosynthesis of Leucomycin, a Macrolide Antibiotic, by CeruleninThe Journal of Biochemistry, 1977