Neuronal Filaments in Alzheimer's, Pick's, and Parkinson's Diseases

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Abstract
To the Editor: Rasool and Selkoe (March 14 issue)1 reported the use of polyclonal antibodies to paired helical filaments and of the monoclonal antibodies RT97 and BF10, which recognize neurofibrillary tangles in Alzheimer's disease. They stated that antibodies to paired helical filaments also reacted with Pick bodies, but not with Lewy bodies. The histology of idiopathic Parkinson's disease is typified by the presence of Lewy bodies in a proportion of neurons chiefly of the substantia nigra, locus ceruleus, and periaqueductal gray.2 The origin and chemistry of Lewy bodies are obscure. In hematoxylin-and-eosin-stained sections, they appear as spherical eosinophilic intracellular inclusions . . .