Analysis of the 2×2 crossover design with subsampling
- 1 January 1993
- journal article
- research article
- Published by Taylor & Francis in Journal of Biopharmaceutical Statistics
- Vol. 3 (1) , 117-127
- https://doi.org/10.1080/10543409308835052
Abstract
Subsampling can be used in experimental design to investigate extraneous sources of variability. One useful strategy is to make independent replicate measurements of the response variate. This can be achieved in clinical studies, for example,by dividing a blood or urine specimen from each of a sample of subjects into aliquots and processing these through a chemistry laboratory in such a way that the replicate determinations are independent. This procedure can be used to increase design efficiency. This paper addresses considerations in the design and analysis of the 2×2 crossover plan with this type of subsampling.Keywords
This publication has 11 references indexed in Scilit:
- Regression toward the mean in 2 × 2 crossover designs with baseline measurementsStatistics in Medicine, 1992
- Recent Developments in Crossover DesignsInternational Statistical Review, 1988
- The two-period crossover design with baseline measurementsCommunications in Statistics - Theory and Methods, 1988
- Some non‐parametric and categorical data analyses for a change‐over design study and discussion of apparent carry‐over effectsStatistics in Medicine, 1983
- Use of baseline measurements in the two-period crossover designCommunications in Statistics - Theory and Methods, 1983
- The Two-Period Crossover TrialJournal of the Royal Statistical Society: Series D (The Statistician), 1982
- Growth Curves in Two-Period Change Over ModelsJournal of the Royal Statistical Society Series C: Applied Statistics, 1981
- Model building and testing for the change‐over designBiometrical Journal, 1980
- 328. Note: The Use of None-Parametric Methods in the Statistical Analysis of the Two-Period Change-Over DesignPublished by JSTOR ,1972
- Analysis and Inference for Incompletely Specified Models Involving the Use of Preliminary Test(s) of SignificanceBiometrics, 1964