On the Interactivity of Complex Synthesis and Tumor Pharmacology in the Drug Discovery Process: Total Synthesis and Comparative in Vivo Evaluations of the 15-Aza Epothilones
- 11 May 2001
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 66 (12) , 4369-4378
- https://doi.org/10.1021/jo010275c
Abstract
No abstract availableKeywords
This publication has 26 references indexed in Scilit:
- A Novel Application of a Pd(0)-Catalyzed Nucleophilic Substitution Reaction to the Regio- and Stereoselective Synthesis of Lactam Analogues of the Epothilone Natural ProductsJournal of the American Chemical Society, 2000
- Synthesis and Biological Evaluation of Aza-EpothilonesChemBioChem, 2000
- New Chemical Synthesis of the Promising Cancer Chemotherapeutic Agent 12,13-Desoxyepothilone B: Discovery of a Surprising Long-Range Effect on the Diastereoselectivity of an Aldol CondensationJournal of the American Chemical Society, 1999
- Total Synthesis of HUN-7293Journal of the American Chemical Society, 1999
- Structure–Activity Relationship of the Epothilones and the First In Vivo Comparison with PaclitaxelAngewandte Chemie International Edition in English, 1997
- Palladium-Catalyzed Cross-Coupling Reactions of Organoboron CompoundsChemical Reviews, 1995
- Total syntheses of (-)-histrionicotoxin and (-)-histrionicotoxin 235AJournal of the American Chemical Society, 1990
- Palladium-catalyzed inter- and intramolecular cross-coupling reactions of B-alkyl-9-borabicyclo[3.3.1]nonane derivatives with 1-halo-1-alkenes or haloarenes. Syntheses of functionalized alkenes, arenes, and cycloalkenes via a hydroboration-coupling sequenceJournal of the American Chemical Society, 1989
- Total synthesis of (.+-.)-chaenorhineJournal of the American Chemical Society, 1983
- The Use of Diethyl Azodicarboxylate and Triphenylphosphine in Synthesis and Transformation of Natural ProductsSynthesis, 1981