Inactivation of Estradiol by the Hepatic Tissues of Mice.

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Abstract
The hepatic tissue of 1st generation hybrid mice, incubated with estradiol in a Warburg apparatus for 1 hr., inactivated 8.5 mouse units/g. of dry wt. The maximum inactivation rate is not affected by the concn. of estradiol in the Warburg flasks. When mice are castrated or castrated and treated with 2 mg. pellets of estrone placed in the subcut. tissues, their hepatic tissues show a significant decrease in the ability to inactivate estradiol. This decrease is evident 6 weeks following the treatment of the mice and is maintained at least 18 mos.