Vasopressin and renin in glycerol-induced acute renal failure in the rat.

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Abstract
Acute renal failure was induced in dehydrated rats by i.m. injection of glycerol (50%, 10 ml/kg). The total period of observation after glycerol injection was 8 h. Hematocrit and plasma osmolality increased transiently and reached maximum values between 1 and 2 h; plasma urea concentration rose progressively during the 8 h period. Plasma levels of arginine-vasopressin had increased 40-fold by 2 h after glycerol injection, whereas plasma renin concentrations were only 2-3 times higher than in controls. Plasma renin substrate concentrations had doubled by 8 h. In rats with acute renal failure, blood pressure was higher than in controls injected with saline. Injection of vasopressin antiserum lowered blood pressure by 10 .+-. 2 (SE) mm Hg, while a competitive antagonist of angiotensin II, saralasin, had no effect. After glycerol injection the increased plasma concentrations of vasopressin induced systemic vasoconstriction. The renin-angiotensin system does not significantly contribute to the rise in systemic vascular resistance.