Betacellulin: a mitogen from pancreatic beta cell tumors
- 12 March 1993
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 259 (5101) , 1604-1607
- https://doi.org/10.1126/science.8456283
Abstract
Betacellulin, a member of the epidermal growth factor family, has been identified in the conditioned medium of cell lines derived from mouse pancreatic beta cell tumors. Betacellulin is a 32-kilodalton glycoprotein that appears to be processed from a larger transmembrane precursor by proteolytic cleavage. The carboxyl-terminal domain of betacellulin has 50 percent sequence similarity with that of rat transforming growth factor alpha. Betacellulin is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.Keywords
This publication has 22 references indexed in Scilit:
- Neu differentiation factor: A transmembrane glycoprotein containing an EGF domain and an immunoglobulin homology unitCell, 1992
- What Is the Evidence That Tumors Are Angiogenesis Dependent?JNCI Journal of the National Cancer Institute, 1990
- Induction of angiogenesis during the transition from hyperplasia to neoplasiaNature, 1989
- Wound Macrophages Express TGF-α and Other Growth Factors in Vivo: Analysis by mRNA PhenotypingScience, 1988
- The Molecular Genetics of CancerScience, 1987
- The neu oncogene encodes an epidermal growth factor receptor-related proteinNature, 1986
- Tyrosine Kinase Receptor with Extensive Homology to EGF Receptor Shares Chromosomal Location with neu OncogeneScience, 1985
- Cloning and sequence analysis of a cDNA for rat transforming growth factor-αNature, 1985
- Rat Transforming Growth Factor Type 1: Structure and Relation to Epidermal Growth FactorScience, 1984
- 125I-labeled human epidermal growth factor. Binding, internalization, and degradation in human fibroblasts.The Journal of cell biology, 1976