On the pathogenesis of intestinal aganglionosis. A consideration based on electron microscopic observations of experimental and clinical aganglionoses

Abstract
A close resemblance in fine structure was observed between the aganglionic colon, produced in rats by serosal application of 0.1% benzalkonium chloride solution, and the aganglionic descending colon, or more proximal segments, of Hirschsprung's disease. The pathogenesis of the disease is discussed.