High seroprevalence of Epstein–Barr virus in children with multiple sclerosis
- 12 December 2006
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 67 (11) , 2063-2065
- https://doi.org/10.1212/01.wnl.0000247665.94088.8d
Abstract
We studied seroprevalence and concentrations of Epstein–Barr virus (EBV) antibodies in 147 pediatric patients with multiple sclerosis (MS) and paired controls. The children with MS showed a near-complete seropositivity for EBV antibody against virus capsid antigen (98.6% vs 72.1% in controls, p = 0.001) but did not display serologic evidence for a recent EBV infection. EBV antibody concentrations of pediatric patients with MS were significantly higher vs controls.Keywords
This publication has 11 references indexed in Scilit:
- Epstein-Barr Virus and Multiple SclerosisArchives of Neurology, 2006
- Infectious mononucleosis and risk for multiple sclerosis: A meta‐analysisAnnals of Neurology, 2006
- Temporal Relationship Between Elevation of Epstein-Barr Virus Antibody Titers and Initial Onset of Neurological Symptoms in Multiple SclerosisJAMA, 2005
- Identification of Epstein-Barr virus proteins as putative targets of the immune response in multiple sclerosisJournal of Clinical Investigation, 2005
- An altered immune response to Epstein-Barr virus in multiple sclerosisNeurology, 2004
- Epstein-Barr Virus in Pediatric Multiple SclerosisJAMA, 2004
- A role of late Epstein-Barr virus infection in multiple sclerosisActa Neurologica Scandinavica, 2004
- Cerebrospinal fluid CD4+T cells from a multiple sclerosis patient cross-recognize Epstein-Barr virus and myelin basic proteinJournal of NeuroVirology, 2004
- The immune response against herpesvirus is more prominent in the early stages of MSNeurology, 2003
- Age at immigration to England of Asian and Caribbean immigrants and the risk of developing multiple sclerosisJournal of Neurology, Neurosurgery & Psychiatry, 1997