Antitubercular Natural Products: Berberine from the Roots of Commercial Hydrastis canadensis Powder. Isolation of Inactive 8-Oxotetrahydrothalifendine, Canadine, β-Hydrastine, and Two New Quinic Acid Esters, Hycandinic Acid Esters-1 and -2
- 3 September 1998
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 61 (10) , 1187-1193
- https://doi.org/10.1021/np9701889
Abstract
Berberine (4) is responsible for the activity of an extract of a commercial root sample of Hydrastis canadensis against multiply drug resistant Mycobacterium tuberculosis. Two new quinic acid feruloyl esters, compounds 2 and 3, have been isolated from the same source along with canadine (1c), 8-oxotetrahydrothalifendine (1), and β-hydrastine (5). These were found to be inactive. The structures of the new compounds were elucidated from spectral (1H, 13C, HMQC, HMBC, and H−H COSY) and chemical evidences.Keywords
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