DONOR-SPECIFIC CELLULAR AND HUMORAL IMMUNITY AFTER CLINICAL KIDNEY TRANSPLANTATION

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Abstract
The cellular and humoral immune response against donor lymphocytes was studied in 10 patients transplanted with kidneys from living related donors. Of the grafts, 9 were functioning well at the time of the study. No direct (T [thymus-derived]) cell-mediated cytotoxicity against donor cells was demonstrated. Specific anti-donor antibodies were found in 2 recipients with well accepted grafts. Their antisera were active in antibody-induced cell-mediated cytotoxicity (AICC) and inhibited the mixed lymphocyte culture (MLC), but were negative in complement-dependent cytotoxicity (CDC). No single immunological factor responsible for a favorable clinical course could be demonstrated. Neither complete T nor complete B [bone marrow-derived] cell tolerance against donor cells had developed, and a well tolerated graft could coexist with antibodies directed against donor cells.

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