Olefin self-metathesis as a new entry into xenotransplantation antagonists bearing the Galili antigen
- 19 February 2002
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 6,p. 594-595
- https://doi.org/10.1039/b111352f
Abstract
A hexameric disaccharide cluster bearing the terminal Galα related xenotransplantation antigen was constructed using a sequence of ruthenium carbenoid catalyzed olefin self-metathesis of monoallylated tribenzyl pentaerythritol followed, after interconversion of benzyl ethers into para-iodobenzyl ethers, by a single step Sonogashira cross-coupling of six prop-2-ynyl glycosides onto a hexameric aryl iodide scaffold.Keywords
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