DNA Haplotype Analysis of CAG Repeat in Taiwanese Huntington’s Disease Patients
- 1 September 2004
- journal article
- research article
- Published by S. Karger AG in European Neurology
- Vol. 52 (2) , 96-100
- https://doi.org/10.1159/000079938
Abstract
We studied the expanded CAG repeat and adjacent CCG repeat in 53 Huntington’s disease (HD) patients and 172 unrelated normal subjects matched to the patients for ethnic origin. The range of the CAG repeat varied from 38 to 109 in the HD patients and from 10 to 29 in the control group. A significant negative correlation was found between the age at onset and the CAG expansion, with no significant influence of the adjacent CCG repeat on the age at onset by multiple regression analysis. Allelic association using CCG repeat and 2 flanking dinucleotide repeat markers within 150 kb of the HD gene revealed linkage disequilibrium for 2 of 3 markers. Haplotype analysis of 24 HD families using these markers identified 3 major haplotypes underlying 87.5% of HD chromosomes. The data suggested frequent haplotypes in the Taiwanese population on which one or more mutational events leading to the disease occurred.This publication has 16 references indexed in Scilit:
- Analysis of CAG and CCG repeats in Huntingtin gene among HD patients and normal populations of IndiaEuropean Journal of Human Genetics, 2000
- Late onset levodopa responsive Huntington's disease with minimal chorea masquerading as Parkinson plus syndromeJournal of Neurology, Neurosurgery & Psychiatry, 2000
- Levodopa responsive parkinsonism in an adult with Huntington's diseaseJournal of Neurology, Neurosurgery & Psychiatry, 1998
- Analysis of triplet repeats in the huntingtin gene in Japanese families affected with Huntington's disease.Journal of Medical Genetics, 1995
- Hereditary Late-Onset Chorea Without Significant DementiaNeurology, 1995
- DNA haplotype analysis of Huntington disease reveals clues to the origins and mechanisms of CAG expansion and reasons for geographic variations of prevalenceHuman Molecular Genetics, 1994
- Analysis of the huntingtin gene reveals a trinucleotide-length polymorphism in the region of the gene that contains two CCG-rich stretches and a correlation between decreased age of onset of Huntington's disease and CAG repeat numberHuman Molecular Genetics, 1993
- A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomesCell, 1993
- Huntington's disease in Chinese: a hypothesis of its origin.Journal of Neurology, Neurosurgery & Psychiatry, 1992