Transformations in the Isoxazole Series: Synthesis of Substituted 2‐Aminothiazoles
- 2 May 1991
- journal article
- research article
- Published by Wiley in Helvetica Chimica Acta
- Vol. 74 (3) , 531-542
- https://doi.org/10.1002/hlca.19910740309
Abstract
Substitued N‐(isoxazol‐4‐yl)thioureas 1 undergo a transformation in the presence of hexacarbonylmolybdenum and acid to yield functionalized thiazoles 3 in a one‐pot reaction. In a few cases, 1,4,5‐trisubstituted dihydroimidazolethiones 4 are also isolated as side products. Mechanistic considerations are outlined and scope and limitations of this new methodology discussed.Keywords
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