Effects of Dietary Stilbestrol upon Certain Endocrine Organs in Lambs

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Abstract
Investigations were conducted to study the interrelationship between dietary stilbestrol and certain endocrine organs and their products using growing wether lambs. Stilbestrol feeding significantly increased pituitary weights, and appreciably increased adrenal weights. When these weights were correlated with body weight, the stilbestrol-fed lamb pituitaries were still significantly larger than their controls. When adrenal weights were correlated with body weight, no differences were observed. Adrenal cholesterol levels, interpreted as being indicative of adrenal function, were significantly higher in the stilbestrol-fed lambs. Stilbestrol feeding resulted in a significant increase in pituitary growth hormone. Gonadotropin levels were significantly reduced as a result of estrogen feeding. Hormone administration, however, apparently had little influence upon pituitary levels of1 ACTH and thyrotropin. Copyright © . .

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