CIRCADIAN AND SEASONAL-VARIATIONS OF SOME METABOLIC PARAMETERS IN SERUM OF ALBINO LABORATORY RAT (RATTUS-NORWEGICUS VAR-ALBA)

  • 1 January 1977
    • journal article
    • research article
    • Vol. 26  (4) , 379-384
Abstract
Total protein [TP], glucose [GL], esterified fatty acids [EFA] and total cholesterol [TC] were determined at 4 h intervals during the 24 h cycle in the serum of 270 female Wistar rats in Feb., May and July. The results can be summed up as follows. The differences found between the levels of the given parameters were statistically highly significant. The greatest differences were observed in the TC level, which was lowest in July [0.82 mmol/l] and highest in Feb. [1.87 nmol/l]. The highest TP and GL values were found in May [62.5 g/l; 10.69 nmol/l] and the lowest in Feb. [40.1 g/l; 7.8 nmol/l]. The smallest differences were observed in the EFA level, which was highest in July [8.09 meq/l] and lowest in Feb. [6.39 meq/l]. The minimum 24 h variations in the levels of most of the given parameters during the 24 h cycle were observed in May [compared with Feb. and July]. In a study of TP and GL concentration, the time of day was found to be a very important factor. The maximum TP level during the 24 h cycle was found most often in the early morning or forenoon, while the blood glucose level was highest about midday and in some cases in the early morning. The blood cholesterol level was relatively stable during the 24 h cycle and it is impossible to draw definite conclusions from its fluctuations. Changes in the EFA level during the 24 h cycle were likewise irregular. Except for cholesterol interindividual differences in the levels of the given parameters in the various months seem to be statistically non-significant.

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