COMPARISON OF CHLOROTHIAZIDE AND MERALLURIDE

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Abstract
A new method for ascertaining diuretic efficacy, carried out in bed-patients in congestive failure within the framework of a highly effective therapeutic regimen which included rest, digitalization, and salt restriction, was applied in a comparison of the maximally effective doses of chlorothiazide and meralluride, a 2-Gm. oral dose of the former and a 2-cc. intramuscular dose of the latter. Each patient received both agents, but not simultaneously, the sequence alternating within and between patients. The comparisons were made in terms of 24-hour weight losses. Only the first four doses with paired responses provided the data which were analyzed by signs and the sign test, also by ratios with confidence limits. Contrary to the prevailing opinion, the 2-Gm. oral dose of chlorothiazide was found to exert only 40% of the diuretic effect of the 2-cc. intramuscular dose of meralluride.

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