Synthesis of (.+-.)-carba-analogs of 5-HPETE and leukotriene A4,unstable intermediates of slow-reacting substance (SRS).

1 January 1982

journal article
Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN

Vol. 30 (1) , 379-382
https://doi.org/10.1248/cpb.30.379

Abstract

The carba-analogs of 5-HPETE and leukotriene A₄, unstable intermediates of slow-reacting substance (SRS), were synthesized. These carbaanalogs inhibited the 5-lipoxygenase. The carba-analog of leukotriene A₄ was a particularly potent specific inhibitor of the 5-lipoxygenase.

Keywords

UNSTABLE
LEUKOTRIENE A4
CARBA ANALOGS
CARBAANALOGS
HPETE AND LEUKOTRIENE

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