Histophysiological effects of an antiandrogen (cyproterone acetate) on the testis of the frog Rana temporaria

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Abstract
An attempt was made to study the effects of cyproterone acetate (CA), an antiandrogen, on the testicular activity of the frog Rana temporaria, employing histological and histochemical methods. Each treated frog received a total dose of 4 mg during the period of 4 weeks. Light-microscopic examinations revealed that CA blocked the formation of spermatids and mature sperms; however, the early stages of spermatogenesis, i.e. proliferation and development of spermatogonia and spermatocytes, remained unaffected. CA caused interstitial tissue disruption and degeneration, and led to the shrinkage of Leydig cells; the drug stopped the production of lipoidal material in the interstitial tissues. Also, a loss of testicular weight was documented in the frogs treated with CA.

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