Comparison of Continuously Collected Urines From the Two Normal Kidneys and Some Effects of Unilateral Denervation

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Abstract
A method for chronic continuous urine collection from the two separate kidneys is described. In successful preparations, presumably normal urine may be collected for at least several weeks. The excretions from the two sides are compared and are quite similar, with differences being greatest for sodium excretion. For a variable period following unilateral renal denervation excretion of water, sodium, osmotically active solutes and creatinine may be greater from the denervated kidney than the normal. The differences usually decrease markedly or vanish with time. Any chronic influence of renal denervation in the normal resting dog on sodium excretion, if present, is minor as compared with that of other factors such as mechanically induced unilateral slight fall in GFR, which may result in diminution of sodium output of constricted kidney to only 10 or 20% that of unmolested kidney. Renal vascular sympathetic tone in the resting untraumatized dog is very small or absent within the limits of experimental error.

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