Effects of Cholecystokinin (CCK)-4, Nonsulfated CCK-8, and Sulfated CCK-8 on Pancreatic Somatostatin, Insulin, and Glucagon Secretion in the Dog: Studiesin Vitro*
- 1 May 1984
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 114 (5) , 1770-1775
- https://doi.org/10.1210/endo-114-5-1770
Abstract
The effect of cholecystokinin (CCK)-4, nonsulfated CCK-8 (CCK-8) and sulfated CCK-8 (CCK-8-S) on endocrine pancreas function was investigated in the isolated perfused dog pancreas in the presence of 5.5 mM glucose. CCK-4 and CCK-8 at concentrations of 1, 10 and 100 nM dose-dependently stimulated pancreatic SRIF [somatostatin], insulin and glucagon release. The insulinotropic and glucagonotropic potency of CCK-8 was significantly greater than that of CCK-4; the effect on SRIF secretion was similar. CCK-8-S and CCK-8 at concentrations of 0.1, 1 and 10 nM caused a dose-dependent increase in pancreatic A, .beta. and D cell secretion. The CCK-8-S was a more potent insulinotropic agent than CCK-8. Apparently, these principal molecular CCK forms qualify for a physiological modulatory role in the endocrine pancreas.This publication has 1 reference indexed in Scilit: