Frequency of p53 Tumor Suppressor Gene Mutations in Human Primary Brain Tumors
- 1 November 1993
- journal article
- Published by Wolters Kluwer Health in Neurosurgery
- Vol. 33 (5) , 824-831
- https://doi.org/10.1227/00006123-199311000-00006
Abstract
MUTATIONS IN THE p53 tumor suppressor gene are the most common genetic alterations found in diverse types of human cancer, including the primary malignant brain tumor, glioblastoma multiforme. To estimate the frequency of p53 mutations in human brain tumors, we screened 120 human primary braKeywords
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