Amezinium metilsulfate, a sympathomimetic agent, may increase the risk of urinary retention in multiple system atrophy
- 1 February 2003
- journal article
- Published by Springer Nature in Clinical Autonomic Research
- Vol. 13 (1) , 51-53
- https://doi.org/10.1007/s10286-003-0034-5
Abstract
In 5 patients with multiple system atrophy, administration of 15 mg/day of amezinium metilsulfate, an adrenergic agent, during 6 months for the treatment of postural hypotension exacerbated post-micturition residuals as compared to that before treatment (178 ml versus 113 ml for a change of 37 %, p < 0.05). Amezinium metilsulfate most probably stimulates both α1B-receptors in the vascular wall and α1A/D-receptors in the proximal urethra.Keywords
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