A rapid method for the selective analysis of total urinary metabolites of inorganic arsenic.

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Abstract
Total urinary As was traditionally used for assessing occupational exposure to inorganic As. Dietary As, especially from seafood, may influence this value. A fast and convenient method for routinely measuring the combined amount of inorganic As, methylarsonic acid and dimethylarsinic acid, the major urinary metabolites after exposure to inorganic As was described. Organic As compounds of marine origin were not biotransformed to inorganic As or methylated As acids to any significance in the human body. They did not produce arsines when treated with reducing agents in the proposed method and did not interfere with the measurements. The sensitivity, accuracy and precision of the proposed method were sufficient for the determination of concentrations of As normally found in the urine of nonexposed persons. The method was based on a commercially available hydride generation kit attached to an atomic absorption spectrophotometer.