Cell cycle arrest following exposure of EBV‐immortalised B‐cells to gamma irradiation correlates with inhibition of cdk2 activity
Open Access
- 20 November 1998
- journal article
- Published by Wiley in FEBS Letters
- Vol. 439 (3) , 297-301
- https://doi.org/10.1016/s0014-5793(98)01391-x
Abstract
The exposure of Epstein‐Barr virus immortalised B cells (LCLs) to the genotoxic effects of gamma irradiation causes a decreased proliferation of the cells. The early events in this process have been investigated here. The induction of p53 expression correlates with a cell cycle arrest in the G1 and G2/M phases of the cell cycle within 24 h of exposure. The molecular mechanism governing the decreased proliferation appears to involve the induction of the cyclin dependent kinase (cdk) inhibitor p21CIP1 and its functional association with cdk2.Keywords
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