Highly Enantioselective Addition of Diethylzinc to Diphenylphosphinoyl Imines under Dual Amino Alcohol/Halosilane Mediation
- 13 September 2000
- journal article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 2 (20) , 3157-3159
- https://doi.org/10.1021/ol006354c
Abstract
Arylethylene-derived, enantiomerically pure amino alcohols have been evaluated as ligands for the dual-catalyzed (amino alcohol/halosilane) enantioselective addition of diethylzinc to diphenylphosphinoyl imines. Among them, the conformationally restricted 9-fluorenone-derived ligand 4c provides the highest enantioselectivities so far reported over a range of substrate imines.Keywords
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